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Efracea

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  • Package contains 56 modified-release hard capsules of Efracea®, each containing 40 milligrams of doxycycline
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What is Efracea?

Efracea is a medicine containing the active ingredient doxycycline. It is used in adults to reduce the amount of pimples or red bumps on the face caused by a skin condition called rosacea. It is prescribed at a low dose (40mg), which helps to manage the inflammatory component of rosacea.

It comes in a capsule form which is convenient and easy to take.

How does Efracea work?

Efracea contains a low dose of doxycycline, which works by controlling the inflammatory processes that cause rosacea symptoms, such as redness and bumps.

Rosacea is an inflammatory skin condition which occurs when certain white blood cells, called neutrophils, become overactive. Efracea helps to decrease the activity of these cells as well as block the actions of enzymes and inflammatory chemicals. In turn, this soothes swelling, redness, and breakouts.

What are the benefits of Efracea?

Other than treating the symptoms of rosacea, Efracea has the following benefits:

  • It contains a low dose of doxycycline, meaning that it can be taken for a longer period of time.
  • A lower dose of the active ingredient means that it may also cause fewer side effects. This makes it easier for patients to tolerate.
  • It is convenient to take as it requires only one dose per day, which makes it easy to incorporate into your daily routine.

How effective is Efracea for rosacea?

Efracea has been shown to be effective in treating rosacea in two studie involving 537 patients with rosacea.

In these studies, the participants that took Efracea experienced a greater decrease in the number of inflamed skin lesions (small red bumps called papules and pus-filled bumps called pustules) compared to the group that took the placebo.

The results from the first study showed that the participants taking Efracea saw, on average, 11.8 fewer lesions than they had at the start. Participants in the placebo group saw an average decrease of only 5.9 lesions.

In the second study, participants taking Efracea experienced, on average, 9.5 fewer lesions than they had to start with, while participants in the placebo group only had an average decrease of 4.3 lesions.

Graph showing the results of Efracea vs Placebo in 2 studies

Who can and cannot take Efracea?

Efracea is approved for use in adults suffering from rosacea who need a safe, long-term option to manage their symptoms.

At euroClinix, to be approved for a prescription, you must have been previously diagnosed with rosacea and have used Efracea before.

Who cannot use it?

Efracea should not be used by patients who are allergic to the active ingredient, to other tetracyclines, or to any of the other ingredients in this medication.

It should be avoided by:

  • pregnant women (especially in the second and third trimester)
  • those receiving treatment with oral retinoids
  • patients with achlorhydria (inability to produce stomach acid)
  • people who have had surgery in the upper part of the gut

Talk to your doctor before taking Efracea if you:

  • have liver disease
  • are prone to developing yeast infections or are currently experiencing an oral or vaginal yeast or fungal infection
  • have myasthenia gravis (a muscle disease)
  • suffer from colitis (inflammation in the colon)
  • experience irritation or ulceration in the oesophagus (the tube that connects your mouth to your stomach)
  • have rosacea that affects the eye
  • have an intolerance to some sugars, or a lack certain digestive enzymes
  • expose yourself to a lot of sunlight

How do I take Efracea?

Dosages

To treat rosacea, the daily dose of Efracea is 40 mg (1 capsule) taken once daily.

When to use it

This medication should be preferably taken in the morning. It should be taken on an empty stomach, at least one hour prior to or two hours after a meal.

How to use it

Make sure to follow the directions given to you by our medical team. To take this medicine correctly, follow the instructions below:

  1. take one capsule once daily, preferably in the morning
  2. swallow the capsule whole and do not chew it
  3. make sure you take the capsule with a full glass of water whilst sitting or standing

It’s important to sit upright or stand when taking this medicine to reduce the risk of throat irritation and ulceration.

Dr. Caroline Fontana Lead Prescribing Doctor

What should I do if I miss a dose?

If you miss a dose, skip the missed dose and take your next dose at your regular time. Do not take a double dose to make up for a missed capsule.

How long does Efracea last?

Efracea capsules are modified-release, which means that the medication is slowly released into the body. It takes around 21 hours for 50% of the medicine to be removed from the blood, which is why you only need to take one capsule each day.

How long does it take to work?

In clinical studies, some patients noticed a reduction in lesions as early as 3 weeks, however, results vary among patients.

Patients taking this medicine should be evaluated after 6 weeks and if there's no improvement, your doctor may decide to stop the treatment.

What lifestyle changes should I make while using Efracea?

Some lifestyle changes should be made when taking this medicine to ensure it remains effective, and to reduce the risk of potential side effects.

Sun protection

  • Avoid too much sunlight or artificial UV light
  • Apply sunscreen with a high SPF
  • Cover up when going outdoors
  • Report any skin reactions to your doctor and stop treatment

Skincare

  • Choose fragrance-free, gentle products
  • Ensure skincare and makeup products are non-comedogenic
  • Avoid products containing alcohol, or other harsh ingredients

Avoid rosacea triggers, such as:

  • changes in temperature
  • spicy foods
  • alcohol
  • stress
  • air pollution
  • smoking

What are Efracea’s side effects?

Common side effects (may affect 1 to 10 patients in 100):
  • inflammation of the nose and throat
  • inflammation of the sinuses
  • fungal infection
  • anxiety
  • headache
  • increased blood pressure
  • diarrhoea
  • pain in the upper abdomen
  • dry mouth
  • back pain
  • pain
  • changes in some blood glucose or liver function tests
Rare side effects (may affect 1 to 10 patients in 10,000):
  • a change in the quantity or type of blood cells
  • elevated pressure in the brain
  • inflammation of the heart’s membranes
  • nausea or vomiting
  • liver damage
  • hives or itchy skin and eyes
Very rarely, patients may experience an allergic reaction, symptoms may include:
  • swelling of the face, lips, tongue and throat
  • difficulty breathing
  • a rapid heartbeat
  • feeling faint

If you experience any serious side effects or an allergic reaction, you should stop using the capsules immediately and consult your healthcare provider. For a full list of possible side effects, consult the patient information leaflet.

How to manage side effects of Efracea:

Some side effects of this medication must be reported to your doctor whereas others may be able to be managed at home:

Fungal infections

Doxycycline can lead to overgrowth of yeast, so watch for signs like itching, discharge, or discomfort.

Speak to your doctor if you develop an infection, they may prescribe antifungal treatments.

Headache

Make sure to stay hydrated and drink plenty of water throughout the day.

Use over-the-counter pain relief medications to help relieve mild headaches. Check with your doctor before using these to ensure they’re safe for you.

Dry mouth

Stay hydrated throughout the day. Suck on sugar-free lozenges or chew gum to help stimulate saliva production.

Avoid caffeine and alcohol as these can contribute to a dry mouth.


If you experience side effects, such as diarrhoea, I would recommend eating bland foods such as plain rice, bananas, or toast to help soothe your stomach. If your symptoms last longer than a few days, you should speak to your doctor.

Silvia Fonda Nutritionist

What interacts with Efracea?

Tell your doctor or pharmacist if you are taking, or might take any other medicines, supplements or natural health products.

In particular, tell your doctor if you are taking any of the following:

  • isotretinoin (for acne)
  • antacids, or other treatments for heartburn
  • some multivitamins or products containing calcium (e.g. milk and dairy products), aluminium, magnesium, zinc, iron, bismuth, cholestyramine, activated charcoal or sucralfate
  • certain blood thinners
  • some diabetes medications (e.g. sulphonylureas)
  • certain antibiotics (e.g. penicillins)
  • barbiturates (medicines that dampen down the central nervous system)
  • rifampicin (for tuberculosis)
  • seizure medications (e.g. carbamazepine, phenytoin, primidone)
  • cyclosporin (for organ transplants)
  • methoxyfluorane (general anaesthetic)

What safety advice should be followed when using Efracea?

For more information, refer to the safety information table below:

Category Status Advice
Alcohol Avoid It's best to avoid alcohol while taking this medicine because it can affect the way it works.
It may also increase the risk of side effects.
Pregnancy Avoid This medicine should not be used in pregnancy, especially in the second and third trimesters as it can cause permanent discolouration in the teeth of infants.
Breastfeeding Avoid This medicine should not be used by breastfeeding mothers for long periods as it may cause tooth discolouration and reduced bone growth in infants.
Driving Safe Efracea does not affect your ability to drive or operate machinery.

How do I store Efracea?

Store these capsules in their original packaging to protect them from light. Make sure it is kept out of the sight and reach of children.

Disposal

Do not use this medicine after the expiry date stated on the outer pack. Please note, the expiry date refers to the last day of the month.

Do not throw the medicine in your household waste. Take any unused or expired medication to your local pharmacy to dispose of correctly.

Can I buy Efracea without a prescription?

No, Efracea is a prescription-only medication because it contains doxycycline, which is a type of antibiotic. This means that a doctor needs to evaluate your condition to ensure that this medicine is the right treatment for your rosacea, as well as monitor any potential side effects or interactions with other medications you might be taking.

Can I buy Efracea online in the UK?

Yes, you can buy Efracea online at euroClinix. The process is quick and convenient.

All you have to do is follow these simple steps:

  1. Complete a quick online consultation to check your eligibility.
  2. UK-registered doctors review your responses to ensure the medication is right for you.
  3. Upon approval, an e-prescription will be issued.
  4. Enjoy free delivery from our licensed pharmacy with tracking details.

Your privacy is our top priority. euroClinix uses secure, encrypted transactions and complies with UK’s medical standards to keep your information confidential.

Start your online consultation today to enjoy professional care from the comfort of your home.

Why should I choose euroClinix?

euroClinix is trusted by thousands of users in the UK for its safe and convenient service. Here’s why:

  • Experienced doctors manage your consultations and prescriptions.
  • Online consultations, quick approvals, and discreet doorstep delivery add to the convenience.
  • A supportive team is on hand to answer treatment-related questions or concerns.
  • Patients can manage their prescriptions hassle-free through our secure platform.

Join thousands who trust euroClinix for their healthcare needs and take control of your health today.

How much is Efracea?

The price of Efracea at euroClinix includes everything you need:

  • Free online consultation with our experienced doctors
  • Free prescription, if approved
  • Free delivery straight to your door

Our pricing is transparent, with no hidden fees. Order today and benefit from our complete, all-inclusive service.

What alternatives are available?

If Efracea is not suitable for you, we have other rosacea treatment options available. Refer to the table below to

Efracea Finacea Metronidazole
Active ingredient Doxycycline Azelaic acid Metronidazole
Form Capsules Topical gel Oral and gel
Side effects Inflammation of the nose, throat and sinuses, fungal infections, headache, diarrhoea, dry mouth Burning, pain, itching, a tingling sensation, dry skin Nausea, vomiting, diarrhoea, skin reactions

Efracea FAQs

Is there any food or drink I need to avoid?
Can I use Efracea long-term?
Can Efracea cure rosacea?
Can I wear makeup while using Efracea?
Are there any discounts for being a new user?
Is it safe to buy Efracea online?
Will my order be confidential?
Are there any charges for delivery?

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 27-11-2024
Efracea information
Type of medicineAntibiotic
Used forThe treatment of rosacea
Active ingredient(s)Doxycycline
Works byTargets inflammation caused by rosacea
Effective within6 weeks
Available asHard capsules
Available strength40 mg
UsageTake one capsule once daily, preferably in the morning
ManufacturerGalderma Ltd
Is a generic available?No
StorageStore in the original packaging to protect from light
Prescription required?Yes, get it FREE with our online consultation
Who is suitable for an online consultation*Adults who have been diagnosed with rosacea and used Efracea before
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